Avaliação da eficácia e segurança do ácido mandélico no tratamento da acne: uma revisão Ácido mandélico no tratamento da acne
Main Article Content
Abstract
Acne is the most prevalent skin disease and represents an unsightly alteration of the skin, which can leave scars and psychological consequences. Currently chemical peeling is a very common aesthetic procedure in the fight against acne. Mandelic acid (MA) has been used in chemical peeling procedures because it has antiseptic and antibacterial properties. This work aims to review the literature regarding the efficacy and safety of the use of mandelic acid in the treatment of acne. It is, therefore, a qualitative integrative review, in which the search for scientific articles was carried out between the period from January 2008 to August 2021, in the PubMed, Bireme, SciELO and LILACS databases. The descriptors Acne Vulgaris, Acne Conglobata, Chloracne, mandelic acids combined through the Boolean operator OR/AND were used. As inclusion criteria, randomized clinical trials published in Portuguese, English and Spanish were selected, addressing the issue of efficacy and/or safety of mandelic acid in the treatment of acne. 19 articles were located, of which 8 were duplicates. Thus, 11 articles were screened with exploratory reading of title and abstract. Of these, five articles were selected for full reading and data extraction. It was concluded that the use of mandelic acid in association with other acids proved to be effective and safe in the treatment of acne. However, it cannot be concluded that its isolated use is effective and safe. Therefore, further studies are needed to demonstrate the efficacy and safety of the isolated use of mandelic acid in the treatment of acne.
Article Details

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
We transfer the copyright pertaining to the manuscript, accepted for publication in this journal, to the exclusive property of Cadernos da Escola de Saúde, and we agree that partial or total reproduction in any means of dissemination, printed or electronic, without the prior and necessary authorization is requested from the Journal's Board of Directors.
References
2. Neves CR, Dias CAA, Garcia JT, Dias SAD. A vivência da acne e as suas consequências psicológicas. Brazilian Journal of Health Review, 2021; 4(1): 1266-94.
3. SBD. Sociedade Brasileira de Dermatologia. Acne. SBD, 2017.
4. Salles FA, Jalil, SMA. Cosmetologia: Benefício do ácido salicílico na acne de I grau. Rev. Conexão Eletrônica. 2018; 15(1): 662-75.
5. Cunha BLS, Ferreira LA. Peeling de ácido salicílico no tratamento da acne: Revisão baseada em evidencias clinicas. Id on line Ver. Mult. Psic. 2018; 12(42): 383-98.
6. Arif T O. Ácido salicílico como agente de peeling: uma revisão abrangente. Dermatologia clínica, cosmética e investigacional. 2015; 8:455-61.
7. Nolasco IMM, Resende JR. Uso do ácido mandélico no tratamento de hipercromias pós-inflamatória: uma revisão de literatura. Scire Solutis. 2020;10(2):35-42.
8. Yokomizo VMF, Benemond TMH, Chisaki C, Benemond PH. Pelling químicos: revisão e aplicação prática. Surg Cosmet Dermatol 2013; 5(1): 58-68.
9. Souza MT, Silva MD, Carvalho R. Revisão integrativa: o que é e como fazer. Einstein, 2010; 8 (1):102-6
10. Moher D, Liberati A, Tetzlaff J, Altman DG. The PRISMA Group, Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLoS Med. 2019; 6(7): e1000097
11. Dayal S, Kalra KD, Sahu P. Comparative study of efficacy and safety of 45% mandelic acid versus 30% salicylic acid peels in mild-to-moderate acne vulgaris. J Cosmet Dermatol. 2020;19(2):393-9.
12. Sarkar R, Ghunawat S, Garg VK. Comparative Study of 35% Glycolic Acid, 20% Salicylic-10% Mandelic Acid, and Phytic Acid Combination Peels in the Treatment of Active Acne and Postacne Pigmentation. J Cutan Aesthet Surg. 2019; 12(3):158-163.
13. Garofalo V, Cannizzaro MV, Mazzilli S, Bianchi L, Campione E. Clinical evidence on the efficacy and tolerability of a topical medical device containing benzoylperoxide 4%, retinol 0.5%, mandelic acid 1% and lactobionic acid 1% in the treatment of mild facial acne: an open label pilot study. Clin Cosmet Investig Dermatol. 2019; 15912):363-9.
14. Nofal E, Nofal A, Gharib K, Nasr M. Abdelshafy A, Elsaid E. Combination chemical peels are more effective than single chemical peel in treatment of mild-to-moderate acne vulgaris: A split face comparative clinical trial. J Cosmet Dermatol. 2018; 17(5):802-10.
15. Garg VK, Sinha S, Sarkar R. Glycolic acid peels versus salicylic-mandelic acid peels in active acne vulgaris and post-acne scarring and hyperpigmentation: a camparative study. Dermatol Surg. 2009; 35(1):59-65.
16. Federman DG, Kirsner RS. Acne vulgaris: pathogenesis and therapeutic approach. Am J Manag Care. 2000; 6(1):78-87.
17. Kontochristopoulos G, Platsidaki E. Chemical peels in active acne and acne scars. Clin Dermatol. 2017; 35(2):179-182.
18. Jartarkar, SR, Gangadhar B, Manjunath P. Um estudo randomizado, simples-cego, ativo controlado para comparar a eficácia do ácido salicílico e do peeling de ácido mandélico no tratamento da acne vulgaris leve a moderadamente grave. Clin Dermatol Rev. 2017; 1:15-8.